People have reported doing this successfully in the past. I think it should work ok, it just depends if your system can handle it. You'll want to be sure not to include the same sites in both instances and also make sure their separate grids do not overlap.
Also, since you'll probably want to set up the same hotkeys in both, you'll want to use the ~ prefix for all of the keynames. So "~A" instead of "A"
Also, since you'll probably want to set up the same hotkeys in both, you'll want to use the ~ prefix for all of the keynames. So "~A" instead of "A"
